The synaptic processes in the periaqueductal gray matter on the model of Parkinson’s disease with hydrocortisone protection
Abstract
Background. Neurodegenerative diseases, notably Parkinson's disease (PD), often result in the impairment of antinociception, leading to chronic pain. Therefore, identifying pharmacological agents capable of protecting against PD development and alleviating associated pain becomes crucial. Aims: to explore the potential protective function of hydrocortisone in PD progression, utilizing the Periaqueductal Gray Matter (PAG) and the Raphe Magnus Nucleus (RMG) as pain models. To this end, the impulse activity of 241 single PAG neurons was examined under three scenarios: normal conditions, a rotenone model of PD, and a rotenone model of PD + hydrocortisone, with RMG subjected to high-frequency stimulation (100 Hz for 1 second). Results. Under normal conditions, RMG neuron activity demonstrated a frequency range of 3 to 17 Hz, indicative of a balanced interplay between inhibitory and excitatory post-stimulus activities. Conversely, in the rotenone model of PD, neuron activity escalated to 124 to 150 Hz, signifying a significant imbalance, with an absence of a predominance of either inhibitory or excitatory post-stimulus activities. Notably, when hydrocortisone was applied in conjunction with the rotenone model, neuron activity normalized to a frequency range of 3 to 5 Hz, restoring the initial balance. Statistical analysis employing the χ² criterion revealed that the frequency distributions in the control group and the hydrocortisone-protected PD model were statistically indistinguishable at a significance level of p < 0.05. Conclusion. The findings underscore the efficacy of Hydrocortisone in safeguarding against PD development. This suggests a promising avenue for incorporating Hydrocortisone as an initial pharmacological strategy in the management of pain associated with PD.
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